Phone: 03-5715131#33452 & #42486
Publications
Structural and mechanistic insights into nitrate transport in AtNRT1.1: The impact of His356 protonation and Thr101 phosphorylation effect.
Protein Science
2026
Yen, C.-Y., Huang, Y.-S., Lin, M.-G., Sun, X.-H., Tsay, Y.-F., Sun, Y.-J., & Hsiao, C.-D.
Revealing the glutamate switch: Insights into proton translocation in plant H+-pyrophosphatase
Biophysical Journal
2025
Huang, Y.-S.;Tsai, J.-Y.;Lin, S.-M.;Wang, S.-C.;Hsiao, C.-D.;Sun, Y.-J.
Using AlphaFold and Symmetrical Docking to Predict Protein–Protein Interactions for Exploring Potential Crystallization Conditions
Proteins: Structure, Function and Bioinformatics
2025
Liao, K.-J.;Sun, Y.-J.
Computational molecular characterization of a novel SLC20A2 variant associated with primary familial brain calcification
Scientific Reports
2025
Lan, S.-C.;Huang, Y.-S.;Tsai, J.-Y.;Lan, M.-Y.;Sun, Y.-J.;Chang, Y.-Y.
KIF2C promotes paclitaxel resistance by depolymerizing polyglutamylated microtubules
Developmental Cell
2025
Pao, Y.-S.;Liao, K.-J.;Shiau, Y.-C.;Chao, M.-H.;Li, M.-C.;Lin, L.-M.;Chang, H.-H.;Yeh, H.-W.;Chen, Y.-J.;Chiu, Y.-T.,etc
Unraveling the structure and function of a novel SegC protein interacting with the SegAB chromosome segregation complex in Archaea
Nucleic Acids Research
2024
Lin, M.-G.;Yen, C.-Y.;Shen, Y.-Y.;Huang, Y.-S.;Ng, I.W.;Barillà, D.;Sun, Y.-J.;Hsiao, C.-D.
Insights into the molecular mechanism of ParABS system in chromosome partition by HpParA and HpParB
Nucleic Acids Research
2024
Chu, C.-H.;Wu, C.-T.;Lin, M.-G.;Yen, C.-Y.;Wu, Y.-Z.;Hsiao, C.-D.;Sun, Y.-J.
Solution structure of bilayer membrane-embedded proton-translocating pyrophosphatase revealed via small-angle X-ray scattering
Materials Chemistry and Physics
2023
Shih, O.;Yeh, Y.-Q.;Liao, K.-F.;Li, K.-M.;Tsai, J.-Y.;Li, C.-C.;Chiang, Y.-W.;Heenan, R.K.;Sun, Y.-J.;Jeng, U.-S.
Crystal structure of Leptospira LSS_01692 reveals a dimeric structure and induces inflammatory responses through Toll-like receptor 2-dependent NF-κB and MAPK signal transduction pathways
FEBS Journal
2023
Hsu, S.-H.;Wu, C.-T.;Sun, Y.-J.;Chang, M.-Y.;Li, C.;Ko, Y.-C.;Chou, L.-F.;Yang, C.-W.
Chromosome segregation in Archaea: SegA- and SegB-DNA complex structures provide insights into segrosome assembly
Nucleic acids research
2021
Yen, C.-Y.;Lin, M.-G.;Chen, B.-W.;Ng, I.W.;Read, N.;Kabli, A.F.;Wu, C.-T.;Shen, Y.-Y.;Chen, C.-H.;Barillà, D.,etc
Crystal structure of Leptospira leucine-rich repeat 20 reveals a novel E-cadherin binding protein to induce NGAL expression in HK2 cells
Biochemical journal
2020
Hsu, S.-H.;Chu, C.-H.;Tian, Y.-C.;Chang, M.-Y.;Chou, L.-F.;Sun, Y.-J.;Yang, C.-W.
Integrative Model to Coordinate the Oligomerization and Aggregation Mechanisms of CCL5
Journal of Molecular Biology
2020
Chen, Y.-C.;Chen, S.-P.;Li, J.-Y.;Chen, P.-C.;Lee, Y.-Z.;Li, K.-M.;Zarivach, R.;Sun, Y.-J.;Sue, S.-C.
Structure of the sodium-dependent phosphate transporter reveals insights into human solute carrier SLC20
Science advances
2020
Tsai, J.-Y.;Chu, C.-H.;Lin, M.-G.;Chou, Y.-H.;Hong, R.-Y.;Yen, C.-Y.;Hsiao, C.-D.;Sun, Y.-J.
Roles of the Hydrophobic Gate and Exit Channel in Vigna radiata Pyrophosphatase Ion Translocation
Journal of Molecular Biology
2019
Tsai, J.-Y.;Tang, K.-Z.;Li, K.-M.;Hsu, B.-L.;Chiang, Y.-W.;Goldman, A.;Sun, Y.-J.
Crystal structures of HpSoj-DNA complexes and the nucleoid-adaptor complex formation in chromosome segregation
Nucleic acids research
2019
Chu, C.-H.;Yen, C.-Y.;Chen, B.-W.;Lin, M.-G.;Wang, L.-H.;Tang, K.-Z.;Hsiao, C.-D.;Sun, Y.-J.
Human CCL5 trimer: Expression, purification and initial crystallographic studies
Acta Crystallographica Section F: Structural Biology Communications
2018
Chen, Y.-C.;Li, K.-M.;Zarivach, R.;Sun, Y.-J.;Sue, S.-C.
Insights into the mechanism of membrane pyrophosphatases by combining experiment and computer simulation
Structural Dynamics
2017
Shah, N.R.;Wilkinson, C.;Harborne, S.P.D.;Turku, A.;Li, K.-M.;Sun, Y.-J.;Harris, S.;Goldman, A.
Membrane pyrophosphatases from Thermotoga maritima and Vigna radiata suggest a conserved coupling mechanism
Nature Communications
2016
Li, K.-M.;Wilkinson, C.;Kellosalo, J.;Tsai, J.-Y.;Kajander, T.;Jeuken, L.J.C.;Sun, Y.-J.;Goldman, A.
Helicobacter pylori cell binding factor 2: Insights into domain motion
Journal of Structural Biology
2016
Naveen, V.;Chu, C.-H.;Chen, B.-W.;Tsai, Y.-C.;Hsiao, C.-D.;Sun, Y.-J.
Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae
Scientific Reports
2016
Chang, M.-Y.;Cheng, Y.-C.;Hsu, S.-H.;Ma, T.-L.;Chou, L.-F.;Hsu, H.-H.;Tian, Y.-C.;Chen, Y.-C.;Sun, Y.-J.;Hung, C.-C.,etc
Insights into ParB spreading from the complex structure of Spo0J and parS
Proceedings of the National Academy of Sciences of the United States of America
2015
Chen, B.-W.;Lin, M.-H.;Chu, C.-H.;Hsu, C.-E.;Sun, Y.-J.
Substrate-induced changes in domain interaction of vacuolar H+-Pyrophosphatase
Journal of Biological Chemistry
2015
Hsu, S.-H.;Lo, Y.-Y.;Liu, T.-H.;Pan, Y.-J.;Huang, Y.-T.;Sun, Y.-J.;Hung, C.-C.;Tseng, F.-G.;Yang, C.-W.;Pan, R.-L.
SH2B1β Interacts with STAT3 and Enhances Fibroblast Growth Factor 1-Induced Gene Expression during Neuronal Differentiation
Molecular and Cellular Biology
2014
Chang, Y.-J.;Chen, K.-W.;Chen, C.-J.;Lin, M.-H.;Sun, Y.-J.;Lee, J.-L.;Chiu, I.-M.;Chen, L.
Structural insights of the ssDNA binding site in the multifunctional endonuclease AtBFN2 from Arabidopsis thaliana
PLoS ONE
2014
Yu, T.-F.;Maestre-Reyna, M.;Ko, C.-Y.;Ko, T.-P.;Sun, Y.-J.;Lin, T.-Y.;Shaw, J.-F.;Wang, A.H.-J.
Crystal structures of starch binding domain from Rhizopus oryzae glucoamylase in complex with isomaltooligosaccharide: Insights into polysaccharide binding mechanism of CBM21 family
Proteins: Structure, Function and Bioinformatics
2014
Chu, C.-H.;Li, K.-M.;Lin, S.-W.;Chang, M.D.-T.;Jiang, T.-Y.;Sun, Y.-J.
Proton/sodium pumping pyrophosphatases: The last of the primary ion pumps
Current Opinion in Structural Biology
2014
Tsai, J.-Y.;Kellosalo, J.;Sun, Y.-J.;Goldman, A.
Essential calcium-binding cluster of Leptospira LipL32 protein for inflammatory responses through the Toll-like receptor 2 pathway
Journal of Biological Chemistry
2013
Lo, Y.-Y.;Hsu, S.-H.;Ko, Y.-C.;Hung, C.-C.;Chang, M.-Y.;Hsu, H.-H.;Pan, M.-J.;Chen, Y.-W.;Lee, C.-H.;Tseng, F.-G.,etc
Squeezing at entrance of proton transport pathway in proton-translocating pyrophosphatase upon substrate binding
Journal of Biological Chemistry
2013
Huang, Y.-T.;Liu, T.-H.;Lin, S.-M.;Chen, Y.-W.;Pan, Y.-J.;Lee, C.-H.;Sun, Y.-J.;Tseng, F.-G.;Pan, R.-L.
LipL41, a hemin binding protein from Leptospira santarosai serovar shermani
PLoS ONE
2013
Lin, M.-H.;Chang, Y.-C.;Hsiao, C.-D.;Huang, S.-H.;Wang, M.-S.;Ko, Y.-C.;Yang, C.-W.;Sun, Y.-J.
Two unique ligand-binding clamps of Rhizopus oryzae starch binding domain for helical structure disruption of Amylose
PLoS ONE
2012
Jiang, T.-Y.;Ci, Y.-P.;Chou, W.-I.;Lee, Y.-C.;Sun, Y.-J.;Chou, W.-Y.;Li, K.-M.;Chang, M.D.-T.
Crystal structure of a membrane-embedded H+-translocating pyrophosphatase
Nature
2012
Lin, S.-M.;Tsai, J.-Y.;Hsiao, C.-D.;Huang, Y.-T.;Chiu, C.-L.;Liu, M.-H.;Tung, J.-Y.;Liu, T.-H.;Pan, R.-L.;Sun, Y.-J.
Structures of Helicobacter pylori uridylate kinase: Insight into release of the product UDP
Acta Crystallographica Section D: Biological Crystallography
2012
Chu, C.-H.;Liu, M.-H.;Chen, P.-C.;Lin, M.-H.;Li, Y.-C.;Hsiao, C.-D.;Sun, Y.-J.
Interaction surface and topology of Get3-Get4-Get5 protein complex, involved in targeting tail-anchored proteins to endoplasmic reticulum
Journal of Biological Chemistry
2012
Chang, Y.-W.;Lin, T.-W.;Li, Y.-C.;Huang, Y.-S.;Sun, Y.-J.;Hsiao, C.-D.
Mutations altering the interplay between GkDnaC helicase and DNA reveal an insight into helicase unwinding
PLoS ONE
2011
Lo, Y.-H.;Liu, S.-W.;Sun, Y.-J.;Li, H.-W.;Hsiao, C.-D.
Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1
Journal of Biological Chemistry
2010
Chang, Y.-W.;Chuang, Y.-C.;Ho, Y.-C.;Cheng, M.-Y.;Sun, Y.-J.;Hsiao, C.-D.;Wang, C.
Calcium binds to LipL32, a lipoprotein from pathogenic Leptospira, and modulates fibronectin binding
Journal of Biological Chemistry
2010
Tung, J.-Y.;Yang, C.-W.;Chou, S.-W.;Lin, C.-C.;Sun, Y.-J.
Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB
Journal of Structural Biology
2010
Hung, K.-W.;Chang, Y.-W.;Eng, E.T.;Chen, J.-H.;Chen, Y.-C.;Sun, Y.-J.;Hsiao, C.-D.;Dong, G.;Spasov, K.A.;Unger, V.M.,etc
Leptospiral outer membrane lipoprotein LipL32 binding on toll-like receptor 2 of renal cells as determined with an atomic force microscope
Biochemistry
2010
Hsu, S.-H.;Lo, Y.-Y.;Tung, J.-Y.;Ko, Y.-C.;Sun, Y.-J.;Hung, C.-C.;Yang, C.-W.;Tseng, F.-G.;Fu, C.-C.;Pan, R.-L.
Single-Stranded DNA-Binding Protein Complex from Helicobacter pylori Suggests an ssDNA-Binding Surface
Journal of Molecular Biology
2009
Chan, K.-W.;Lee, Y.-J.;Wang, C.-H.;Huang, H.;Sun, Y.-J.
The crystal structure of a replicative hexameric helicase DnaC and its complex with single-stranded DNA
Nucleic Acids Research
2009
Lo, Y.-H.;Tsai, K.-L.;Sun, Y.-J.;Chen, W.-T.;Huang, C.-Y.;Hsiao, C.-D.
Molecular Interplay between the Replicative Helicase DnaC and Its Loader Protein DnaI from Geobacillus kaustophilus
Journal of Molecular Biology
2009
Tsai, K.-L.;Lo, Y.-H.;Sun, Y.-J.;Hsiao, C.-D.
Crystal structures of the 70-kDa heat shock proteins in domain disjoining conformation
Journal of Biological Chemistry
2008
Chang, Y.-W.;Sun, Y.-J.;Wang, C.;Hsiao, C.-D.
Crystal structures of the starch-binding domain from Rhizopus oryzae glucoamylase reveal a polysaccharide-binding path
Biochemical Journal
2008
Tung, J.-Y.;Chang, M.D.-T.;Chou, W.-I.;Liu, Y.-Y.;Yeh, Y.-H.;Chang, F.-Y.;Lin, S.-C.;Qiu, Z.-L.;Sun, Y.-J.
Kinetic and structural properties of triosephosphate isomerase from Helicobacter pylori
Proteins: Structure, Function and Bioinformatics
2008
Chu, C.-H.;Lai, Y.-J.;Huang, H.;Sun, Y.-J.
Dimerization is important for the GTPase activity of chloroplast translocon components atToc33 and psToc159
Journal of Biological Chemistry
2007
Yeh, Y.-H.;Kesavulu, M.M.;Li, H.-M.;Wu, S.-Z.;Sun, Y.-J.;Konozy, E.H.E.;Hsiao, C.-D.
Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification
Nucleic Acids Research
2007
Tsai, K.-L.;Sun, Y.-J.;Huang, C.-Y.;Yang, J.-Y.;Hung, M.-C.;Hsiao, C.-D.
Crystal structure of Helicobacter pylori spermidine synthase: A Rossmann-like fold with a distinct active site
Proteins: Structure, Function and Bioinformatics
2007
Po, K.L.;Tsai, J.-Y.;Hsiang, Y.C.;Huang, H.;Chu, C.-H.;Sun, Y.-J.
Cell adhesion molecule Echinoid associates with unconventional myosin VI/Jaguar motor to regulate cell morphology during dorsal closure in Drosophila
Developmental Biology
2007
Lin, H.-P.;Chen, H.-M.;Wei, S.-Y.;Chen, L.-Y.;Chang, L.-H.;Sun, Y.-J.;Huang, S.-Y.;Hsu, J.-C.
Complexed crystal structure of replication restart primosome protein PriB reveals a novel single-stranded DNA-binding mode
Nucleic Acids Research
2006
Huang, C.-Y.;Hsu, C.-H.;Sun, Y.-J.;Wu, H.-N.;Hsiao, C.-D.
Crystal structure of HP0242, a hypothetical protein from Helicobacter pylori with a novel fold
Proteins: Structure, Function and Bioinformatics
2006
Tsai, J.-Y.;Chen, B.-T.;Cheng, H.-C.;Chen, H.-Y.;Hsaio, N.-W.;Lyu, P.-C.;Sun, Y.-J.
Crystal structure of the human FOXK1a-DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins
Journal of Biological Chemistry
2006
Tsai, K.-L.;Huang, C.-Y.;Chang, C.-H.;Sun, Y.-J.;Chuang, W.-J.;Hsiao, C.-D.
Comparative immunoproteomics of idenfication and characterization of virulence factors from helicobacter pylori related to gastric cancer
Molecular and Cellular Proteomics
2006
Lin, Y.-F.;Wu, M.-S.;Chang, C.-C.;Lin, S.-W.;Lin, J.-T.;Sun, Y.-J.;Chen, D.-S.;Chow, L.-P.
Kinetic and structural properties of inorganic pyrophosphatase from the pathogenic bacterium Helicobacter pylori
Proteins: Structure, Function and Bioinformatics
2006
Chao, T.-C.;Huang, H.;Tsai, J.-Y.;Huang, C.-Y.;Sun, Y.-J.
Cloning and characterization of spermidine synthase and its implication in polyamine biosynthesis in Helicobacter pylori strain 26695
Protein Expression and Purification
2005
Lee, M.-J.;Huang, C.-Y.;Sun, Y.-J.;Huang, H.
Crystallization and preliminary X-ray diffraction analysis of spermidine synthase from Helicobacter pylori
Acta Crystallographica Section D: Biological Crystallography
2004
Lu, P.-K.;Chien, S.-Y.;Tsai, J.-Y.;Fong, C.-T.;Lee, M.J.;Huang, H.;Sun, Y.-J.
Lipid binding in rice nonspecific lipid transfer protein-1 complexes from Oryza sativa
Protein Science
2004
Cheng, H.-C.;Cheng, P.-T.;Peng, P.;Lyu, P.-C.;Sun, Y.-J.
Crystallization and preliminary X-ray diffraction analysis of thermophilic imidase from pig liver
Acta Crystallographica - Section D Biological Crystallography
2003
Huang, C.-Y.;Chiang, S.-K.;Yang, Y.-S.;Sun, Y.-J.
Constrained multiple sequence alignment tool development and its application to RNase family alignment.
Journal of bioinformatics and computational biology
2003
Tang, C.Y.;Lu, C.L.;Chang, M.D.;Tsai, Y.T.;Sun, Y.J.;Chao, K.M.;Chang, J.M.;Chiou, Y.H.;Wu, C.M.;Chang, H.T.,etc
Crystal structure of pea Toc34, a novel GTpase of the chloroplast protein translocon
Nature Structural Biology
2002
Sun, Y.-J.;Forouhar, F.;Li, H.-M.;Tu, S.-L.;Yeh, Y.-H.;Kao, S.;Shr, H.-L.;Chou, C.-C.;Chen, C.;Hsiao, C.-D.
Crystallization and preliminary X-ray diffraction analysis of the 10 kDa C-terminal subdomain of 70 kDa heat-shock cognate protein
Acta Crystallographica Section D: Biological Crystallography
2001
Chou, C.-C.;Wang, C.;Sun, Y.-J.;Shr, H.-L.;Hsiao, C.-D.
The Crystal Structure of a Novel Mammalian Lectin, Ym1, Suggests a Saccharide Binding Site
Journal of Biological Chemistry
2001
Sun, Y.-J.;Chang, N.-C.A.;Hung, S.-I.;Chien Chang, A.;Chou, C.-C.;Hsiao, C.-D.
Boundary sequences of the NADPH oxidase p67phox C-terminal SH3 domain play on its specificity
Biochemical and Biophysical Research Communications
2001
Hwang, S.-L.;Cheng, T.-S.;Chen, C.-H.;Sun, Y.-J.;Hsiao, C.-D.;Hong, Y.-R.
Crystallization and preliminary X-ray diffraction analysis of cytotoxic ribonucleases from bullfrog Rana catesbeiana
Acta Crystallographica Section D: Biological Crystallography
2001
Liu, J.-H.;Liao, Y.-D.;Sun, Y.-J.
The crystal structure of phosphoglucoseisomerase/autocrine motility factor/neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its substrate/receptor recognition
Journal of Biological Chemistry
2000
Chou, C.-C.;Sun, Y.-J.;Meng, H.;Hsiao, C.-D.
Probing the location and function of the conserved histidine residue of phosphoglucose isomerase by using an active site directed inhibitor N- bromoacetylethanolamine phosphate
Protein Science
1999
Meng, M.;Chane, T.-L.;Sun, Y.-J.;Hsiao, C.-D.
The crystal structure of a multifunctional protein: Phosphoglucose isomerase/autocrine motility factor/neuroleukin
Proceedings of the National Academy of Sciences of the United States of America
1999
Sun, Y.-J.;Chou, C.-C.;Chen, W.-S.;Wu, R.-T.;Meng, M.;Hsiao, C.-D.
The structure of glutamine-binding protein complexed with glutamine at 1.94 Å resolution: Comparisons with other amino acid binding proteins
Journal of Molecular Biology
1998
Sun, Y.-J.;Rose, J.;Wang, B.-C.;Hsiao, C.-D.
The three-dimensional structure of an avian class-mu glutathione S-transferase, cGSTM1-1 at 1.94 Å resolution
Journal of Molecular Biology
1998
Sun, Y.-J.;Kuan, I.-C.;Tam, M.F.;Hsiao, C.-D.
Crystal structure of cardiotoxin V from Taiwan cobra venom: pH-dependent conformational change and a novel membrane-binding motif identified in the three-finger loops of p-type cardiotoxin
Biochemistry
1997
Sun, Y.-J.;Chiang, C.-M.;Hsin, A.-Y.;Hsiao, C.-D.
Expression, purification, and crystallization of two isozymes of 6- phosphoglucose isomerase of bacillus stearothermophilus
Journal of Structural Biology
1997
Hsiao, C.-D.;Chou, C.-C.;Hsiao, Y.-Y.;Sun, Y.-J.;Meng, M.
A novel neurotoxin, cobrotoxin b, from Naja naja atra (Taiwan cobra) venom: Purification, characterization, and gene organization
Journal of Biochemistry
1997
Chang, L.-S.;Chou, Y.-C.;Lin, S.-R.;Wu, B.-N.;Lin, J.;Hong, E.;Sun, Y.-J.;Hsiao, C.-D.
The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold
Nature Structural Biology
1997
Liu, Z.-J.;Sun, Y.-J.;Rose, J.;Chung, Y.-J.;Hsiao, C.-D.;Chang, W.-R.;Kuo, I.;Perozich, J.;Lindahl, R.;Hempel, J.,etc
The crystal structure of glutamine-binding protein from Escherichia coli
Journal of Molecular Biology
1996
Hsiao, C.-D.;Sun, S.;Rose, J.;Wang, B.-C.
Crystals of glutamine-binding protein in various conformational states
Journal of Molecular Biology
1994
Hsiao, C.-D.;Sun, Y.-J.;Rose, J.;Cottam, P.F.;Ho, C.;Wang, B.-C.
A novel neurotoxin, cobrotoxin b, from Naja naja atra (Taiwan cobra) venom: Purification, characterization, and gene organization
Journal of Biochemistry
1997
Chang, L.-S.;Chou, Y.-C.;Lin, S.-R.;Wu, B.-N.;Lin, J.;Hong, E.;Sun, Y.-J.;Hsiao, C.-D.
The first structure of an aldehyde dehydrogenase reveals novel interactions between NAD and the Rossmann fold
Nature Structural Biology
1997
Liu, Z.-J.;Sun, Y.-J.;Rose, J.;Chung, Y.-J.;Hsiao, C.-D.;Chang, W.-R.;Kuo, I.;Perozich, J.;Lindahl, R.;Hempel, J.,etc
The crystal structure of glutamine-binding protein from Escherichia coli
Journal of Molecular Biology
1996
Hsiao, C.-D.;Sun, S.;Rose, J.;Wang, B.-C.
Crystals of glutamine-binding protein in various conformational states
Journal of Molecular Biology
1994
Hsiao, C.-D.;Sun, Y.-J.;Rose, J.;Cottam, P.F.;Ho, C.;Wang, B.-C.